April
19,
2019
Angela Koehler, PhD
Department of Biological Engineering
Massachusetts Institute of Technology
Chemical Probe Discovery for Transcription Factors
Transcription Factors govern key cellular processes underlying development and disease. Genetic studies have implicated a number of transcription factors in various cancers. To date, transcription factors have proven to be recalcitrant to traditional drug discovery approaches. A critical path for identifying chemical tools that perturb oncogenic transcription will be presented with emphasis on a recent story related to a chemical probe that attenuates Myc-driven transcription in cellular and animal models.
Host: Weiping Tang
— Please note that this seminar will start 30 minutes earlier than the usual seminar time. —
