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Taeghwan Hyeon, PhDSeoul National University
Hosted by Seungpyo Hong and Weibo Cai
Over the last 20 years, our laboratory has focused on the designed chemical synthesis, assembly and applications of uniform-sized nanocrystals. In particular, we developed a novel generalized procedure called as the “heat-up process” for the direct synthesis of uniform-sized nanocrystals of many metals, oxides, and chalcogenides (Nature Mater. 2004, 3, 891).
We reported that uniform 2 nm iron oxide nanoclusters can be successfully used as T1 MRI contrast agent for high-resolution MR angiography of monkeys (Nature Biomed. Eng. 2017, 1, 637). We demonstrated that ceria nanoparticles and ceria–zirconia nanoparticles can work as therapeutic antioxidants to treat various nasty diseases including ischemic stroke, Alzheimer’s disease, sepsis, and Parkinson’s disease (Angew. Chem. Int. Ed. 2012, 51, 11039; 2017, 56, 11399; 2018, 57, 9408). We report a highly sensitive and selective K+ nanosensor that can quantitatively monitor extracellular K+ concentration changes in the brains of freely moving mice experiencing epileptic seizures (Nature Nanotech. 2019, in revision).
We reported graphene-hybrid electrochemical devices integrated with thermo-responsive micro-needles for the sweat-based diabetes monitoring and feedback therapy (Nature Nanotech. 2016, 11, 566; Science Adv. 2017, 3, e1601314). We introduced electromechanical cardioplasty using an epicardial mesh made of electrically conductive and elastic Ag-Au core-shell nanowire-rubber nanocomposite to resemble the innate cardiac tissue and confer cardiac conduction system function (Science Transl. Med. 2016, 8, 344ra86; Nature Nanotech. 2018, 13, 1048).