Publications

Acknowledging the AIC

AIC users are kindly requested to acknowledge the AIC in all publications made possible, in whole or in part, by the facilities. Your cooperation will assist in documenting supplementary information for future instrumentation grant proposals. Our suggested acknowledgement statement template is:

“The authors wish to acknowledge the Analytical Instrumentation Center of the School of Pharmacy, UW-Madison, for support in obtaining mass spectrometric and/or NMR and/or spectrophotometric data.”

Publication Lists

Presented below are literature references to research publications which involved use of the AIC facilities. Records begin in 2001, the year in which the AIC began operation. Please notify in cases of error or omission, or with suggestions or comments.

Publications Related to the AIC Mass Spectrometry Facility

  1. Singh C., Satwinderjeet Kaur S., George J., Nihal M., Pellitteri Hahn M., Scarlett C., Ahmad N. “Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach.” Oncotarget 6(12):10335-48, 2015
  2. Cholewa, B.D., Pellitteri-Hahn M.C., Scarlett C.O., Ahmad. N. “Large-Scale Label-Free Comparative Proteomics Analysis of Polo-Like Kinase 1 Inhibition via the Small-Molecule Inhibitor BI 6727 (Volasertib) in BRAFV600E Mutant Melanoma Cells.” J Proteome Res 13:5041-50, 2014
  3. Gemperline E., Laha K., Scarlett C.O., Pearce R.A., Li L. “Measurement of NMDA Receptor Antagonist, CPP, in Mouse Plasma and Brain Tissue Following Systematic Administration Using Ion-Pair LCMS/MS.” Anal Methods 6(16):6389-6396, 2014 | View online
  4. Chandra K. Singh, Satwinderjeet Kaur, Jasmine George, Cameron O. Scarlett, Molly C. Pellitteri Hahn, and Nihal Ahmad. “Mechanism of anti-proliferative effects of sanguinarine in melanoma cells: A quantitative large-scale proteomics approach.” American Association for Cancer Research Annual Meeting, San Diego, CA April 5-9, 2014
  5. Brian D. Cholewa, Molly Pellitteri-Hahn, Cameron O. Scarlett, Nihal Ahmad. “Identification of downstream targets of polo-like kinase 1 in melanoma by large-scale label-free comparative.” American Association for Cancer Research Annual Meeting, San Diego, CA April 5-9, 2014
  6. Ma D, Cao W, Kapur A, Felder M, Scarlett CO, Patankar MS, Li L. Differential expression of proteins in naïve and IL-2 stimulated primary human NK cells identified by global proteomic analysis. J Proteomics. 91:151-63, 2013 | View online
  7. Bienengraeber, M., Pellitteri-Hahn, M.C., Naoyuki, H., Baye, T.M., Zeljko, J.B., Olivier, M. "Quantitative characterization of changes in the cardiac mitochondrial proteome during anesthetic preconditioning and ischemia." Physiol. 45:163-170, 2013
  8. Zhang Y, Scarlett C, Hutson P. Stability of carboplatin, paclitaxel, and docetaxel with acetyl-l-carnitine during simulated Y-site administration. Int J Pharm Compd. 16(1):82-5, 2012 | View online
  9. Johnson JJ, Nihal M, Siddiqui IA, Scarlett CO, Bailey HH, Mukhtar H, Ahmad N. Enhancing the bioavailability of resveratrol by combining it with piperine. Mol Nutr Food Res.8:1169-76, 2011 | View online
  10. Zickus, M., Mirza, S., Guillen-Ahlers, H., Cole, R., Pellitteri-Hahn, M., Zelembaba, M. Scalf, M., Cirillo, L., Shortreed, M., Smith, L., and Olivier, M. “Mass Spectrometric Analysis of DNA-Bound Proteins from a Complex Matrix.” 59th ASMS Conference on Mass Spectrometry, Denver CO, June 5-9, 2011
  11. Zickus, M., Mirza, S., Guillen-Ahlers, H., Cole, R., Pellitteri-Hahn, M., Zelembaba, M. Scalf, M., Cirillo, L., Shortreed, M., Smith, L., and Olivier, M. “A Proteomics Approach to Reversing the Chromatin Immunoprecipitation Methodology.” US HUPO 7th Annual Conference, Raleigh, NC, March 20-23, 2011
  12. Brown-Ford, S., DeLaForest, A., Halligan, B., Pellitteri-Hahn, M.C., Duncan S., and Olivier, M. “Proteomic Analysis of Undifferentiated Embryonic Stem Cells.” US HUPO 7th Annual Conference, Raleigh, NC, March 20-23, 2011
  1. Pellitteri-Hahn, M.C., Halligan, B.D., Scalf, M., Smith, L.M., and Hickey W.J. “Quantitative proteomic analysis of the chemolithoautotrophic bacterium Nitrosomonas europaea; Comparison of growing- and energy-starved cells.” J Proteome Res. 74(4): 411-9, 2010
  2. Pellitteri-Hahn, M.C., Bienengraeber, M., Baye, T.M., Zelijiko, B.J., and Olivier, M. “Changes in mitochondrial proteome during anesthetic preconditioning and ischemia.” US HUPO 5th Annual Conference, San Diego, CA, February 22-25, 2009
  3. Han J, Danell RM, Patel JR, Gumerov DR, Scarlett CO, Speir JP, Parker CE, Rusyn I, Zeisel S, Borchers CH. Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry. Metabolomics. 4(2):128-140, 2008
  4. Danell RM, Ouvry-Patat SA, Scarlett CO, Speir JP, Borchers CH. Data Self-Recalibration and Mixture Mass Fingerprint Searching (DASER-MMF) to enhance protein identification within complex mixtures. J Am Soc Mass Spectrom. 19:1914-25, 2008
  5. Bienengraeber, M., Pellitteri-Hahn, M.C., M., Baye, T.M., Zelijiko, B.J., and Olivier, M. “Proteomic analysis to determine the effect of volatile anesthetics on mitochondrial metabolism and bioenergetics.” 11th NHLBI Proteomics Initiative Investigators Meeting, Charleston, SC, April 16-17 2008
  6. Halligan, B.D., Mirza, S.P., Pellitteri-Hahn, M.C., Olivier, M., and Greene, A.S. “Visualizing quantitative proteomics datasets using Treemaps. Information Visualization. 527-4. 2007
  7. Mirza, S.P., Pellitteri, M.C., Winkler, E., Warren, M., Didier, D., Littlrell, J., Halligan, B.D., Twigger, S., Greene, A.S., and Oliver, M. “Quantitative analysis of the rat vascular endothelial cell secretome during hypoxia.” 9th NHLBI Proteomics Initiative Investigators Meeting, Boston, MA, April 18-19 2007
  8. Mirza, S.P., Pellitteri, M.C., Keyes Winkler, E., Warren, M., Didier, D., Littlrell, J., Halligan, B.D., Twigger, S., Greene, A.S., and Oliver, M. “Global quantitative comparison of the cellular proteomes of endothelial cells from consomic rat strains under normoxia and hypoxia.” 55th ASMS Conference on Mass Spectrometry, Indianapolis, IN, June 3-7, 2007
  9. Pellitteri-Hahn, M.C., Warren, M.C., Didier, D.N., Winkler, E.L., Mirza, S.P., Greene, A.S., Olivier, M. “Improved mass spectrometric proteomic profiling of the secretome of rat vascular endothelial cells.” J Proteome Res. 5(10):2861-4, 2006
  10. Pellitteri, M.C., and Hickey, W.J. “Proteomic analysis of Nitrosomonas eurpaea: Comparison of growing and ammonium-starved cells.” 105th General Meeting of the American Society of Microbiology, Atlanta, GA, June 5-9 2005
  11. Scalf, M., Pellitteri, M.C., Halligan, B.D., Westphall, M.S., Hickey W.J., and Smith, L.M. “Quantitative proteomic analysis of metabolically labeled ammonium starvation Nitrosomonas europaea using Zoomquant-N15. 53rd ASMS Conference on Mass Spectrometry, San Antonio, TX, May 24-26 2005
  1. Witte, R.P. and W.Y.J. Kao, Keratinocyte-fibroblast paracrine interaction: the effects of substrate and culture condition. Biomaterials, 2005. 26(17): p. 3673–3682.
  2. Shen, B., Targeted carrier fusions for delivery of chemotherapeutic agents. 2005, (Wisconsin Alumni Research Foundation, USA). Application: WO
    WO. p. 109 pp.
  3. Liu, W., et al., The Neocarzinostatin Biosynthetic Gene Cluster from Streptomyces carzinostaticus ATCC 15944 Involving Two Iterative Type I Polyketide Synthases. Chemistry & Biology, 2005. 12(3): p. 293–302.
  4. Ju, J., et al., Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin. Journal of the American Chemical Society, 2005. 127(6): p. 1622–1623.
  5. Haug, B.E., M. Brewer, and D.H. Rich, Facile degradative lactonization of Gln-Arg and Gln-Phe hydroxyethylene dipeptide derivatives. Journal of Peptide Research, 2005. 65(1): p. 77–83.
  6. Comstock Lindsay, R. and R. Rajski Scott, Conversion of DNA methyltransferases into azidonucleosidyl transferases via synthetic cofactors. Nucleic acids research, 2005. 33(5): p. 1644–52.
  1. Yang, J., L. Liu, and J.S. Thorson, Structure-based enhancement of the first anomeric glucokinase. Chembiochem, 2004. 5(7): p. 992–6.
  2. Witte, R.P., et al., Analysis of poly(ethylene glycol)-diacrylate macromer polymerization within a multicomponent semi-interpenetrating polymer network system. J Biomed Mater Res, 2004. 71A(3): p. 508–18.
  3. Weller, R.L. and S.R. Rajski, Aziridination of g,d-dibromoethyl-2-pentenoate with primary amines: extension of the Gabriel-Cromwell reaction. Tetrahedron Letters, 2004. 45(30): p. 5807–5810.
  4. Tang, G.-L., Y.-Q. Cheng, and B. Shen, Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase. Chemistry & Biology, 2004. 11(1): p. 33–45.
  5. Sukonpan, C., et al., Synthesis of substrates and inhibitors of botulinum neurotoxin type A metalloprotease. Journal of Peptide Research, 2004. 63(2): p. 181–193.
  6. Shen, B. and H.-J. Kwon, Use of type II polyketide synthases to catalyze C-O bond formation. 2004, (Wisconsin Alumni Research Foundation, USA). Application: US
    US. p. 50 pp.
  7. Kutz, K.K., J.J. Schmidt, and L. Li, In situ tissue analysis of neuropeptides by MALDI FTMS in-cell accumulation. Anal Chem, 2004. 76(19): p. 5630–40.
  8. Ju, J., et al., Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861. Chembiochem, 2004. 5(9): p. 1281–5.
  9. Hoffmeister, D. and J.S. Thorson, Mechanistic implications of Escherichia coli
    galactokinase structure-based engineering.
    Chembiochem, 2004. 5(7): p. 989–92.
  10. Haug, B.E. and D.H. Rich, Synthesis of a Gln-Phe Hydroxy-ethylene Dipeptide Isostere. Organic Letters, 2004. 6(25): p. 4783–4786.
  11. Ding, X., et al., Oral absorption enhancement of cromolyn sodium through noncovalent
    complexation.
    Pharmaceutical Research, 2004. 21(12): p. 2196–2206.
  12. Comstock, L.R. and S.R. Rajski, Efficient Synthesis of Azide-Bearing Cofactor Mimics. Journal of Organic Chemistry, 2004. 69(4): p. 1425–1428.
  13. Brewer, M., C.A. James, and D.H. Rich, Synthesis of a tripeptide derivative containing the gln-arg hydroxyethylene dipeptide isostere. Organic Letters, 2004. 6(25): p. 4779–82.
  14. Bililign, T., et al., The hedamycin locus implicates a novel aromatic PKS priming mechanism. Chem Biol, 2004. 11(7): p. 959–69.
  1. Zazopoulos, E., et al., A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nature Biotechnology, 2003. 21(2): p. 187–190.
  2. Yang, J., et al., Studies on the substrate specificity of Escherichia coli galactokinase. Org Lett, 2003. 5(13): p. 2223–6.
  3. Shen, B. and W. Liu, The Streptomyces globisporus gene cluster for biosynthesis of the enediyne antitumor antibiotic C-1027 and the generation of novel variants. 2003, (Wisconsin Alumni Research Foundation, USA). Application: US
    US. p. 119 pp, Cont -in-part of U S Ser No 159,257.
  4. Shen, B., Y.-q. Cheng, and G.-l. Tang, The leinamycin biosynthetic enzymes of Streptomyces atroolivaceus using independent acyltransferase module and the gene cluster encoding them and their uses. 2003, (Wisconsin Alumni Research Foundation, USA).
    Application: US. p. 247 pp, Cont -in-part of Appl No PCT/US02/08937.
  5. Restituyo Jose, A., et al., Conversion of aryl azides to O-alkyl imidates via modified Staudinger ligation. Organic letters, 2003. 5(23): p. 4357–60.
  6. Rajski, S.R., L.R. Comstock, and S.G. Petersen, Progress on the synthesis of functionally diverse aziridine-based cofactor mimetics. American Association of Colleges of Pharmacy Annual Meeting, 2003. 104(JUL): p. NIL_0270.
  7. Liu, W., et al., Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model. Proceedings of the National Academy of Sciences of the United States of America, 2003. 100(21): p. 11959–63.3
  8. Li, J. and W.J. Kao, Synthesis of polyethylene glycol (PEG) derivatives and PEGylatedpeptide biopolymer conjugates. Biomacromolecules, 2003. 4(4): p. 1055–67.
  9. Hyun, C.G., et al., The biosynthesis of indolocarbazoles in a heterologous E. coli host. Chembiochem, 2003. 4(1): p. 114–7.
  10. Hoffmeister, D., et al., Creation of the first anomeric D/L-sugar kinase by means of directed evolution. Proc Natl Acad Sci U S A, 2003. 100(23): p. 13184–9.
  11. Fu, X., et al., Antibiotic optimization via in vitro glycorandomization. Nat Biotechnol, 2003. 21(12): p. 1467–9.
  12. Cheng, Y.-Q., G.-L. Tang, and B. Shen, Type I polyketide synthase requiring a discrete
    acyltransferase for polyketide biosynthesis.
    Proceedings of the National Academy of Sciences of
    the United States of America, 2003. 100(6): p. 3149–54.
  13. Burmania, J.A., G.J. Martinez-Diaz, and W.J. Kao, Synthesis and physicochemical analysis of interpenetrating networks containing modified gelatin and poly(ethylene glycol) diacrylate. J Biomed Mater Res A, 2003. 7(1): p. 224–34.
  14. Biggins, J.B., K.C. Onwueme, and J.S. Thorson, Resistance to enediyne antitumor antibiotics by CalC self-sacrifice. Science, 2003. 301(5639): p. 1537–41.
  15. Albermann, C., et al., Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization. Org Lett, 2003. 5(6): p. 933–6.
  1. Shen, B., Y.-Q. Cheng, and G.-L. Tang, Leinamycin biosynthesis gene cluster of Streptomyces atroolivaceus and its use in the development of leinamycin analogs. 2002, (The Regents of the University of California, USA; Kyowa Hakko Kogyo Co., Ltd.). Application: WO
    WO. p. 185 pp.
  2. Rich, D.H., M.G. Bursavich, and M.A. Estiarte, Discovery of nonpeptide, peptidomimetic peptidase inhibitors that target alternate enzyme active site conformations. Biopolymers, 2002. 66(2): p. 115–25.
  3. Park, Y., et al., Effects of conjugated linoleic acid (CLA) metabolites and cognates in heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes. Faseb Journal, 2002. 16(4): p. A224–A224.
  4. Liu, W., et al., Biosynthesis of the enediyne antitumor antibiotic C-1027. Science, 2002. 297(5584): p. 1170–3.
  5. Kwon, H.J., et al., C-O bond formation by polyketide synthases. Science, 2002. 297(5585): p. 1327–30.
  6. Kao, W.J., J. Li, and D. Lok, Bifunctional-modified hydrogels containing polyethylene glycol derivatives. 2002, (Wisconsin Alumni Research Foundation, USA). Application: WO
    WO. p. 82 pp.
  7. Comstock, L.R. and S.R. Rajski, Expeditious synthesis of aziridine-based cofactor mimics. Tetrahedron, 2002. 58(30): p. 6019–6026.
  8. Cheng, Y.-Q., G.-L. Tang, and B. Shen, Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140. Journal of bacteriology, 2002. 184(24): p. 7013–24.
  9. Bursavich, M.G. and D.H. Rich, Designing Non-Peptide Peptidomimetics in the 21st Century: Inhibitors Targeting Conformational Ensembles. Journal of Medicinal Chemistry, 2002. 45(3): p. 541–558.
  10. Brewer, M. and D.H. Rich, Sequencing hydroxyethylamine-containing peptides via Edman degradation. Organic Letters, 2002. 4(20): p. 3469–72.
  11. Bililign, T., et al., On the origin of deoxypentoses: evidence to support a glucose progenitor in the biosynthesis of calicheamicin. Chembiochem, 2002. 3(11): p. 1143–6.
  12. Ahlert, J., et al., The calicheamicin gene cluster and its iterative type I enediyne PKS. Science, 2002. 297(5584): p. 1173–6.

  1. West, C.W., M.A. Estiarte, and D.H. Rich, New Methods for Side-Chain Protection of Cysteine. Organic Letters, 2001. 3(8): p. 1205–1208.
  2. Travins, J.M., et al., Aspartic Protease Inhibitors: Expedient Synthesis of 2-Substituted Statines. Organic Letters, 2001. 3(17): p. 2725–2728.
  3. Sok, D.E. and C.J. Sih, Difference in susceptibility of tyrosine residue to oxidative iodination between a thioredoxin box region and a hormonogenic region. Archives of Pharmacal Research, 2001. 24(5): p. 446–454.
  4. Ripka, A.S., et al., Aspartic Protease Inhibitors Designed from Computer-Generated Templates Bind As Predicted. Organic Letters, 2001. 3(15): p. 2309–2312.
  5. Rich, D.H., et al., Merging Rational Drug Design with Combinatorial Chemistry: Reasonable and Unreasonable Expectations. Medicinal Chemistry into the Millennium, ed. M.M. Campbell. 2001: I.S. Blagbrough Royal Society of Chemistry. 16–24.
  6. Oost, T.K., C. Sukonpan, and D.H. Rich, Design and synthesis of substrate based inhibitors of botulinum neurotoxin type B metalloprotease. Peptides 2000, Proceedings of the European Peptide Symposium, 26th, Montpellier, France, Sept. 10–15, 2000, 2001: p. 23–25.
  7. Kao, W.J., D. Lok, and J. Li, Preparation of heterodifunctional polyethyleneglycols: network formation, characterization, and cell culture analysis. J Biomater Sci Polym Ed, 2001. 12(6): p. 599–611.
  8. Estiarte, M.A., A.M. Elder, and D.H. Rich, Synthetic progress towards a TMC-95 analog as a potential proteasome inhibitor. Peptides: The Wave of the Future, Proceedings of the Second International and the Seventeenth American Peptide Symposium, San Diego, CA, United States, June 9–14, 2001, 2001: p. 532–533.
  9. Dales, N.A., et al., Design and Synthesis of Unsymmetrical Peptidyl Urea Inhibitors of Aspartic Peptidases. Organic Letters, 2001. 3(15): p. 2313–2316.
  10. Bursavich, M.G., C.W. West, and D.H. Rich, From Peptides to Non-Peptide Peptidomimetics: Design and Synthesis of New Piperidine Inhibitors of Aspartic Peptidases. Organic Letters, 2001. 3(15): p. 2317–2320.
  11. Bursavich, M.G. and D.H. Rich, Solid-Phase Synthesis of Aspartic Peptidase Inhibitors:
    3-Alkoxy-4-Aryl Piperidines.
    Organic Letters, 2001. 3(17): p. 2625–2628.
  12. Bursavich, M.G. and D.H. Rich, Solution and solid phase synthesis of non-peptide peptidomimetic aspartic peptidase inhibitors. Peptides: The Wave of the Future, Proceedings of the Second International and the Seventeenth American Peptide Symposium, San Diego, CA, United States, June 9–14, 2001, 2001: p. 537–538.
  13. Brewer, M. and D.H. Rich, Synthesis of a Tripeptide Derivative Containing the Phe-Arg Hydroxyethylene Dipeptide Isostere. Organic Letters, 2001. 3(6): p. 945–948.
  14. Brewer, M. and D.H. Rich, One-pot conversion of azides to protected guanidines via the Staudinger reduction; synthesis and utilization of the Phe-Arg hydroxyethylene dipeptide isostere. Peptides: The Wave of the Future, Proceedings of the Second International and the Seventeenth American Peptide Symposium, San Diego, CA, United States, June 9–14, 2001, 2001: p. 40–41.

Publications & Abstracts Related to the AIC NMR Facility

  1. Witte, R.P. and W.Y.J. Kao, Keratinocyte-fibroblast paracrine interaction: the effects of substrate and culture condition. Biomaterials, 2005. 26(17): p. 3673–3682.
  2. Ju, J., et al., Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin. Journal of the American Chemical Society, 2005. 127(6): p. 1622–1623.
  3. Haug, B.E., M. Brewer, and D.H. Rich, Facile degradative lactonization of Gln-Arg and Gln-Phe hydroxyethylene dipeptide derivatives. Journal of Peptide Research, 2005. 65(1): p. 77–83.
  4. Comstock Lindsay, R. and R. Rajski Scott, Conversion of DNA methyltransferases into azidonucleosidyl transferases via synthetic cofactors. Nucleic acids research, 2005. 33(5): p.1644–52.
  1. Zilinski, J.L. and W.J. Kao, Tissue adhesiveness and host response of in situ photopolymerizable interpenetrating networks containing methylprednisolone acetate. J Biomed Mater Res A, 2004. 68(2): p. 392–400.
  2. Witte, R.P., et al., Analysis of poly(ethylene glycol)-diacrylate macromer polymerization within a multicomponent semi-interpenetrating polymer network system. J Biomed Mater Res, 2004. 71A(3): p. 508–18.
  3. Weller, R.L. and S.R. Rajski, Aziridination of g,d-dibromoethyl-2-pentenoate with primary amines: extension of the Gabriel-Cromwell reaction. Tetrahedron Letters, 2004. 45(30): p. 5807–5810.
  4. Sukonpan, C., et al., Synthesis of substrates and inhibitors of botulinum neurotoxin type A metalloprotease. Journal of Peptide Research, 2004. 63(2): p. 181–193.
  5. Ju, J., et al., Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861. Chembiochem, 2004. 5(9): p. 1281–5.
  6. Jette, K.K., et al., Preparation and Drug Loading of Poly(Ethylene Glycol)-block-Poly(e-Caprolactone) Micelles Through the Evaporation of a Cosolvent Azeotrope. Pharmaceutical Research, 2004. 21(7): p. 1184–1191.
  7. Hoang, K.C. and S. Mecozzi, Aqueous solubilization of highly fluorinated molecules by semifluorinated surfactants. Langmuir, 2004. 20(18): p. 7347–7350.
  8. Hoang, K. and S. Mecozzi, Encapsulation of highly fluorinated drugs by semifluorinated
    block copolymers.
    Polymer Preprints (American Chemical Society, Division of Polymer
    Chemistry), 2004. 45(1): p. 965–966.
  9. Haug, B.E. and D.H. Rich, Synthesis of a Gln-Phe Hydroxy-ethylene Dipeptide Isostere. Organic Letters, 2004. 6(25): p. 4783–4786.
  10. Goncalves, E., R.J. Debs, and T.D. Heath, The effect of liposome size on the final lipid/DNA ratio of cationic lipoplexes. Biophys J, 2004. 86(3): p. 1554–63.
  11. Ding, X., T.C. Stringfellow, and J.R. Robinson, Self-association of cromolyn sodium in aqueous solution characterized by nuclear magnetic resonance spectroscopy. Journal of Pharmaceutical Sciences, 2004. 93(5): p. 1351–1358.
  12. Ding, X., et al., Oral absorption enhancement of cromolyn sodium through noncovalent complexation. Pharmaceutical Research, 2004. 21(12): p. 2196–2206.
  13. Comstock, L.R. and S.R. Rajski, Efficient Synthesis of Azide-Bearing Cofactor Mimics. Journal of Organic Chemistry, 2004. 69(4): p. 1425–1428.
  14. Brewer, M., C.A. James, and D.H. Rich, Synthesis of a tripeptide derivative containing
    the gln-arg hydroxyethylene dipeptide isostere.
    Organic Letters, 2004. 6(25): p. 4779–82.
  15. Adams, M. and G.S. Kwon, Spectroscopic investigation of the aggregation state of amphotericin B during loading, freeze-drying, and reconstitution of polymeric micelles. Journal of Pharmacy & Pharmaceutical Sciences, 2004. 7(4): p. 1–6.
  1. Yang, J., et al., Studies on the substrate specificity of Escherichia coli galactokinase. Org Lett, 2003. 5(13): p. 2223–6.
  2. Restituyo Jose, A., et al., Conversion of aryl azides to O-alkyl imidates via modified Staudinger ligation. Organic letters, 2003. 5(23): p. 4357–60.
  3. Rajski, S.R., L.R. Comstock, and S.G. Petersen, Progress on the synthesis of functionally diverse aziridine-based cofactor mimetics. American Association of Colleges of Pharmacy Annual Meeting, 2003. 104(JUL): p. NIL_0270.
  4. Martinez-Diaz, G.J., et al., Mechanical and chemical analysis of gelatin-based hydrogel degradation. Macromolecular Chemistry and Physics, 2003. 204(15): p. 1898–1908.
  5. Li, J. and W.J. Kao, Synthesis of polyethylene glycol (PEG) derivatives and PEGylatedpeptide biopolymer conjugates. Biomacromolecules, 2003. 4(4): p. 1055–67.
  6. Kao, W.J. and Y. Liu, Intracellular protein tyrosine phosphorylation of adherent human macrophages on adsorbed fibronectin. Biomaterials, 2003. 24(7): p. 1183–91.
  7. Hoffmeister, D., et al., Creation of the first anomeric D/L-sugar kinase by means of directed evolution. Proc Natl Acad Sci U S A, 2003. 100(23): p. 13184–9.
  8. Fu, X., et al., Antibiotic optimization via in vitro glycorandomization. Nat Biotechnol, 2003. 21(12): p. 1467–9.
  9. Einerson, N.J., K.R. Stevens, and W.J. Kao, Synthesis and physicochemical analysis of gelatin-based hydrogels for drug carrier matrices. Biomaterials, 2003. 24(3): p. 509–23.
  10. Burmania, J.A., K.R. Stevens, and W.J. Kao, Cell interaction with protein-loaded interpenetrating networks containing modified gelatin and poly(ethylene glycol) diacrylate. Biomaterials, 2003. 24(22): p. 3921–30.
  11. Burmania, J.A., G.J. Martinez-Diaz, and W.J. Kao, Synthesis and physicochemical analysis of interpenetrating networks containing modified gelatin and poly(ethylene glycol) diacrylate. J Biomed Mater Res A, 2003. 67(1): p. 224–34.
  12. Albermann, C., et al., Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization. Org Lett, 2003. 5(6): p. 933–6.
  13. Adams, M.L. and G.S. Kwon, Relative aggregation state and hemolytic activity of amphotericin B encapsulated by poly(ethylene oxide)-block-poly(N-hexyl-L-aspartamide)-acyl conjugate micelles: effects of acyl chain length. J Control Release, 2003. 87(1-3): p. 23–32.
  14. Adams, M.L., D.R. Andes, and G.S. Kwon, Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules, 2003. 4(3): p.
    750–7.
  1. Stevens, K.R., et al., In vivo biocompatibility of gelatin-based hydrogels and interpenetrating networks. J Biomater Sci Polym Ed, 2002. 13(12): p. 1353–66.
  2. Rich, D.H., M.G. Bursavich, and M.A. Estiarte, Discovery of nonpeptide, peptidomimetic peptidase inhibitors that target alternate enzyme active site conformations. Biopolymers, 2002. 66(2): p. 115–25.
  3. Park, Y., et al., Effects of conjugated linoleic acid (CLA) metabolites and cognates in heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes. Faseb Journal, 2002. 16(4): p. A224–A224.
  4. Kao, W.J., J. Li, and D. Lok, Bifunctional-modified hydrogels containing polyethylene glycol derivatives. 2002, (Wisconsin Alumni Research Foundation, USA). Application: WO
    WO. p. 82 pp.
  5. Goncalves, E. and T.D. Heath, The effect of liposome size on lipoplex formation: The relationship between mixing and final lipid: DNA lipoplex ratios. Biophysical Journal, 2002. 82(1): p. 536A–536A.
  6. Comstock, L.R. and S.R. Rajski, Expeditious synthesis of aziridine-based cofactor mimics. Tetrahedron, 2002. 58(30): p. 6019–6026.
  7. Bursavich, M.G. and D.H. Rich, Designing Non-Peptide Peptidomimetics in the 21st Century: Inhibitors Targeting Conformational Ensembles. Journal of Medicinal Chemistry, 2002. 45(3): p. 541–558.
  8. Brewer, M. and D.H. Rich, Sequencing hydroxyethylamine-containing peptides via Edman degradation. Organic Letters, 2002. 4(20): p. 3469–72.
  9. Adams, M.L. and G.S. Kwon, The effects of acyl chain length on the micelle properties of poly(ethylene oxide)-block-poly(N-hexyl-L-aspartamide)-acyl conjugates. J Biomater Sci Polym Ed, 2002. 13(9): p. 991–1006.

  1. West, C.W., M.A. Estiarte, and D.H. Rich, New Methods for Side-Chain Protection of Cysteine. Organic Letters, 2001. 3(8): p. 1205–1208.
  2. Travins, J.M., et al., Aspartic Protease Inhibitors: Expedient Synthesis of 2-Substituted Statines. Organic Letters, 2001. 3(17): p. 2725–2728.
  3. Sok, D.E. and C.J. Sih, Difference in susceptibility of tyrosine residue to oxidative iodination between a thioredoxin box region and a hormonogenic region. Archives of Pharmacal Research, 2001. 24(5): p. 446–454.
  4. Ripka, A.S., et al., Aspartic Protease Inhibitors Designed from Computer-Generated Templates Bind As Predicted. Organic Letters, 2001. 3(15): p. 2309–2312.
  5. Rich, D.H., et al., Merging Rational Drug Design with Combinatorial Chemistry: Reasonable and Unreasonable Expectations. Medicinal Chemistry into the Millennium, ed. M.M. Campbell. 2001: I.S. Blagbrough Royal Society of Chemistry. 16–24.
  6. Oost, T.K., C. Sukonpan, and D.H. Rich, Design and synthesis of substrate based inhibitors of botulinum neurotoxin type B metalloprotease. Peptides 2000, Proceedings of the European Peptide Symposium, 26th, Montpellier, France, Sept. 10–15, 2000, 2001: p. 23–25.
  7. Kao, W.J., D. Lok, and J. Li, Preparation of heterodifunctional polyethyleneglycols: network formation, characterization, and cell culture analysis. J Biomater Sci Polym Ed, 2001. 12(6): p. 599–611.
  8. Estiarte, M.A., A.M. Elder, and D.H. Rich, Synthetic progress towards a TMC-95 analog as a potential proteasome inhibitor. Peptides: The Wave of the Future, Proceedings of the Second International and the Seventeenth American Peptide Symposium, San Diego, CA, United States, June 9–14, 2001, 2001: p. 532–533.
  9. Dales, N.A., et al., Design and Synthesis of Unsymmetrical Peptidyl Urea Inhibitors of Aspartic Peptidases. Organic Letters, 2001. 3(15): p. 2313–2316.
  10. Bursavich, M.G., C.W. West, and D.H. Rich, From Peptides to Non-Peptide Peptidomimetics: Design and Synthesis of New Piperidine Inhibitors of Aspartic Peptidases. Organic Letters, 2001. 3(15): p. 2317–2320.
  11. Bursavich, M.G. and D.H. Rich, Solid-Phase Synthesis of Aspartic Peptidase Inhibitors: 3-Alkoxy-4-Aryl Piperidines. Organic Letters, 2001. 3(17): p. 2625–2628.
  12. Bursavich, M.G. and D.H. Rich, Solution and solid phase synthesis of non-peptide peptidomimetic aspartic peptidase inhibitors. Peptides: The Wave of the Future, Proceedings of the Second International and the Seventeenth American Peptide Symposium, San Diego, CA, United States, June 9–14, 2001, 2001: p. 537–538.
  13. Brewer, M. and D.H. Rich, Synthesis of a Tripeptide Derivative Containing the Phe-Arg Hydroxyethylene Dipeptide Isostere. Organic Letters, 2001. 3(6): p. 945–948.
  14. Brewer, M. and D.H. Rich, One-pot conversion of azides to protected guanidines via the Staudinger reduction; synthesis and utilization of the Phe-Arg hydroxyethylene dipeptide isostere. Peptides: The Wave of the Future, Proceedings of the Second International and the Seventeenth American Peptide Symposium, San Diego, CA, United States, June 9–14, 2001,
    2001: p. 40–41.

Publications Related to the AIC Spectrophotometry Facility

  1. Witte, R.P. and W.Y.J. Kao, Keratinocyte-fibroblast paracrine interaction: the effects of substrate and culture condition. Biomaterials, 2005. 26(17): p. 3673–3682.
  2. Comstock Lindsay, R. and R. Rajski Scott, Conversion of DNA methyltransferases into azidonucleosidyl transferases via synthetic cofactors. Nucleic acids research, 2005. 33(5): p.1644–52.
  1. Witte, R.P., et al., Analysis of poly(ethylene glycol)-diacrylate macromer polymerization within a multicomponent semi-interpenetrating polymer network system. J Biomed Mater Res, 2004. 71A(3): p. 508–18.
  2. Weller, R.L. and S.R. Rajski, Aziridination of g,d-dibromoethyl-2-pentenoate with primary amines: extension of the Gabriel-Cromwell reaction. Tetrahedron Letters, 2004. 45(30):p. 5807–5810.
  3. Smith, L.J., et al., Sedative effects and serum drug concentrations of oxymorphone and metabolites after subcutaneous administration of a liposome-encapsulated formulation in dogs. Journal of Veterinary Pharmacology & Therapeutics, 2004. 27(5): p. 369–372.
  4. McAnulty, J.F., et al., Suppression of cold ischemic injury in stored kidneys by the antimicrobial peptide bactenecin. Cryobiology, 2004. 49(3): p. 230–40.
  5. Lee, T.W.-Y. and J.R. Robinson, Drug Delivery to the Posterior Segment of the Eye II: Development and Validation of a Simple Pharmacokinetic Model for Subconjunctival Injection. Journal of Ocular Pharmacology and Therapeutics, 2004. 20(1): p. 43–53.
  6. Lee, T.W.-Y. and J.R. Robinson, Drug Delivery to the Posterior Segment of the Eye III: The Effect of Parallel Elimination Pathway on the Vitreous Drug Level After Subconjunctival Injection. Journal of Ocular Pharmacology and Therapeutics, 2004. 20(1): p. 55–64.
  7. Hoang, K.C. and S. Mecozzi, Aqueous solubilization of highly fluorinated molecules by semifluorinated surfactants. Langmuir, 2004. 20(18): p. 7347–7350.
  8. Goncalves, E., R.J. Debs, and T.D. Heath, The effect of liposome size on the final lipid/DNA ratio of cationic lipoplexes. Biophys J, 2004. 86(3): p. 1554–63.
  9. Croy, S.R. and G.S. Kwon, The effects of Pluronic block copolymers on the aggregation state of nystatin. J Control Release, 2004. 95(2): p. 161–71.
  10. Comstock, L.R. and S.R. Rajski, Efficient Synthesis of Azide-Bearing Cofactor Mimics. Journal of Organic Chemistry, 2004. 69(4): p. 1425–1428.
  11. Clark, M.D., et al., Evaluation of liposome-encapsulated oxymorphone hydrochloride in mice after splenectomy. Comparative Medicine, 2004. 54(5): p. 558–563.
  12. Smith, L.J., et al., A single dose of liposome-encapsulated oxymorphone or morphine provides long-term analgesia in an animal model of neuropathic pain. Comparative Medicine, 2003. 53(3): p. 280–287.
  1. Restituyo Jose, A., et al., Conversion of aryl azides to O-alkyl imidates via modified Staudinger ligation. Organic letters, 2003. 5(23): p. 4357–60.
  2. Rajski, S.R., L.R. Comstock, and S.G. Petersen, Progress on the synthesis of functionally diverse aziridine-based cofactor mimetics. American Association of Colleges of Pharmacy Annual Meeting, 2003. 104(JUL): p. NIL_0270.
  3. Krugner-Higby, L., et al., Liposome-encapsulated oxymorphone hydrochloride provides prolonged relief of postsurgical visceral pain in rats. Comp Med, 2003. 53(3): p. 270–9.
  1. Goncalves, E. and T.D. Heath, The effect of liposome size on lipoplex formation: The relationship between mixing and final lipid: DNA lipoplex ratios. Biophysical Journal, 2002. 82(1): p. 536A–536A.
  2. Comstock, L.R. and S.R. Rajski, Expeditious synthesis of aziridine-based cofactor mimics. Tetrahedron, 2002. 58(30): p. 6019–6026.
  3. Bursavich, M.G. and D.H. Rich, Designing Non-Peptide Peptidomimetics in the 21st Century: Inhibitors Targeting Conformational Ensembles. Journal of Medicinal Chemistry, 2002. 45(3): p. 541–558.
  4. Amin, K., et al., Cell association of liposomes with high fluid anionic phospholipid content is mediated specifically by LDL and its receptor, LDLr. J Pharm Sci, 2002. 91(5): p.1233–44.
  5. Adams, M.L. and G.S. Kwon, The effects of acyl chain length on the micelle properties of poly(ethylene oxide)-block-poly(N-hexyl-L-aspartamide)-acyl conjugates. J Biomater Sci Polym Ed, 2002. 13(9): p. 991–1006.

  1. Lee, T.W.-Y. and J.R. Robinson, Drug delivery to the posterior segment of the eye: some insights on the penetration pathways after subconjunctival injection. Journal of Ocular Pharmacology and Therapeutics, 2001. 17(6): p. 565–572.
  2. Amin, K., et al., LDL induced association of anionic liposomes with cells and delivery of contents as shown by the increase in potency of liposome dependent drugs. Pharm Res, 2001. 18(7): p. 914–21.
  3. Amin, K. and T.D. Heath, LDL-induced association of anionic liposomes with cells and delivery of contents – II. Interaction of liposomes with cells in serum-containing medium. Journal of Controlled Release, 2001. 73(1): p. 49–57.