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Publications

  1. Sun, Y.; Zhu, L.; Kearns, K. L.; Ediger, M. D.; Yu, L. Glasses Crystallize Rapidly at Surfaces by Growing Crystals Upward. Proc. Natl. Acad. Sci. 2011, in press.
  2. Dawson, K. J.; Zhu, L.; Yu, L.; Ediger, M. D Anisotropic structure and transformation kinetics of vapor-deposited indomethacin glasses.  J. Phys. Chem. B. 2011, 115, 455-463.
  3. Yu, L. Polymorphism in Molecular Solids: An Extraordinary System of Red, Orange, and Yellow Crystals.  Acc. Chem. Res. 2010, 43, 1257-1266.  Cover article.
  4. Zhu, L.; Yu, L. Generality of Forming Stable Organic Glasses by Vapor Deposition.  Chem. Phys. Lett. 2010, 499, 62–65.
  5. Sun, Y.; Tao, J.; Zhang, G. G. Z.; Yu, L. Solubilities of Crystalline Drugs in Polymers: Improved Analytical Method and Comparison of Solubilities of Indomethacin and Nifedipine in PVP, PVP/VA, and PVAc.  J. Pharm. Sci. 2010, 99, 4023-4031.
  6. Strydom, S.; Liebenberg, W.; Yu, L.; de Villiers, M. The effect of temperature and moisture on the amorphous-to-crystalline transformation of stavudine. Int. J. Pharmaceutics 2009, 379, 72-81.
  7. Sun, Y.; Xi, H.; Ediger, M. D.; Richert, R.; Yu, L. Diffusion-Controlled and “Diffusionless” Crystal Growth near the Glass Transition Temperature: Relation between Liquid Dynamics and Growth Kinetics of Seven ROY Polymorphs.  J. Chem. Phys. 2009, 131, 074506/1-074506/9.
  8. Strydom, S.; Zhu, L.; Yu, L.; de Villiers, M. Ultra-Thin Coatings for Stabilizing Amorphous Drugs against Surface-Enhanced Crystallization. Scientia 2009, September Issue.
  9. Zhao, J.; Ediger, M. D.; Sun, Ye; Yu, L.  Two DSC Glass Transitions in Miscible Blends of Polyisoprene/Poly(4-tert-butylstyrene). Macromolecules 2009, 42, 6777-6783.
  10. Dawson, K. J; Kearns, K. L; Yu, L.; Steffen, W.; Ediger, M. D. Physical vapor deposition as a route to hidden amorphous states.  Proc. Nat. Acad. Sci. 2009, 106, 15165-15170.
  11. Kearns, K. L.; Sun, Y.; Swallen, S. F.; Yu, L.; Ediger, M. D. Calorimetric evidence of two distinct molecular packings in stable glasses of indomethacin. J. Phys. Chem. B 2009, 113, 1579-1586.
  12. Xi, H.; Sun, Y.; Yu, L. Diffusion-controlled and Diffusionless Crystal Growth in Liquid o-Terphenyl near Its Glass Transition Temperature.  J. Chem. Phys. 2009, 130, 094508/1 – 094508/9.
  13. Tao, J.; Sun, Y.; Zhang, G. G. D.; Yu, L. Solubility of Small-Molecule Crystals in Polymers: D-Mannitol in PVP, Indomethacin in PVP/VA, and Nifedipine in PVP/VA.  Pharm. Res. 2009, 26, 855 – 864.  No. 1 most viewed paper of Pharm. Res. online (4681 times by 28 Feb. 2011; http://www.pharmagateway.net/MostViewedArticles.aspx?JournalID=11095).
  14. Zhu, L.; Wong, L.; Yu, L. Surface-Enhanced Crystallization of Amorphous Nifedipine.  Scientia 2008, September Issue.
  15. Huang, J.; Stringfellow, T. C.; Yu, L. Glycine Exists Mainly as Monomers, Not Dimers, in Supersaturated Aqueous Solutions: Implications for Understanding Its Crystallization and Polymorphism.  J. Am. Chem. Soc. 2008, 130, 13973-13980.
  16. Zhu, L.; Wong, L.; Yu, L. Surface-Enhanced Crystallization of Amorphous Nifedipine.  Molecular Pharmaceutics 2008, 5, 921-926.
  17. Kearns, K. L.; Swallen, S. F.; Ediger, M. D.; Wu, T.; Sun, Y.; Yu, L.  Hiking down the Energy Landscape: Progress toward the Kauzmann Temperature via Vapor Deposition. J. Phys. Chem. B 2008, 112, 4934-4942.
  18. Sun, Y.; Xi, H.; Chen, S.; Ediger, M. D.; Yu, L. Crystallization near Glass Transition: Transition from Diffusion-Controlled to Diffusionless Crystal Growth Studied with Seven Polymorphs.  J. Phys. Chem. B 2008, 112, 5594-5601.
  19. Sun, Y.; Xi, H.; Ediger, M. D.; Yu, L. Diffusionless Crystal Growth from Glass Has Precursor in Equilibrium Liquid.  J. Phys. Chem. B 2008, 112, 661-664.
  20. Ediger, M.; Harrowell, P.; Yu, L. Crystal Growth Kinetics Depend on Liquid Fragility.  J. Chem. Phys. 2008, 128, 034709/1-034709/6.
  21. Yu, L. Survival of the fittest polymorph: how fast nucleater can lose to fast grower.  CrystEngComm, 2007, 9, 847 – 851.  Invited Highlight.
  22. Tao, J.; Yu, L. Cross-Nucleation between D-Mannitol Polymorphs in Seeded Crystallization.  Cryst. Growth & Design 2007, 7, 2410-2414.
  23. Kearns, K. L.; Swallen, S. F.; Ediger, M. D.; Wu, T.; Yu, L.  Influence of Substrate Temperature on the Stability of Glasses Prepared by Vapor Deposition.  J. Chem. Phys. 2007, 127, 154702.
  24. Ishida, H.; Wu, T.; Yu, L. Sudden Acceleration of Crystal Growth of Nifedipine near Tg without and with Polyvinylpyrrolidone.  J. Pharm. Sci. 2007, 96, 1131-8.
  25. Wu, T.; Sun, Y.; Li, N.; de Villiers, M.; Yu, L. Inhibiting Surface Crystallization of Amorphous Indomethacin by Nanocoating.  Langmuir 2007, 23, 5148-5153.
  26. Milton, N.; Gopalrathnam, G.; Craig, G. D.; Mishra, D. S.; Roy, M. L.; Yu, L.  Vial breakage during freeze-drying: crystallization of sodium chloride in sodium chloride-sucrose frozen aqueous solutions.  J. Pharm. Sci. 2007, 96, 1848-1853.
  27. Kanatzidis, Mercouri G.; Poeppelmeier, Kenneth R.; Bobev, Svilen; Guloy, Arnold M.; Hwu, Shiou-Jyh; Lachgar, Abdou; Latturner, Susan E.; Schaak, Raymond E.; Seo, Dong-Kyun; Sevov, Slavi C.; Stein, Andreas; Dabrowski, Bogdan; Greedan, John E.; Greenblatt, Martha; Grey, Clare P.; Jacobson, Allan J.; Keszler, Douglas A.; Li, Jing; Subramanian, Mas A.; Xia, Younan; Cagin, Tahir; Haeussermann, Ulrich; Hughbanks, Timothy; Mahanti, S. D.; Morgan, Dane; Seo, Dong-Kyun; Spaldin, Nicola A.; Buhro, William E.; Giammar, Daniel E.; Hollingsworth, Jennifer A.; Johnson, David C.; Nozik, Arthur J.; Peng, Xiaogang; Bedard, Robert L.; Brese, Nathaniel E.; Cao, Guang; Dhingra, Sandeep S.; Kagan, Cherie R.; Mitzi, David B.; Geselbracht, Margret J.; Lisensky, George C.; Lufaso, Michael W.; Maggard, Paul A.; Michael, O'Keeffe; Wilkinson, Angus P.; zur Loye, Hans-Conrad; Egami, Takeshi; Greedan, John E.; Hodges, Jason P.; Martin, James D.; Parise, John B.; Toby, Brian H.; Vanderah, Terrell A.; Burns, Peter C.; Chan, Julia Y.; Meyer, Anne E.; Murray, Christopher B.; Ramirez, Arthur P.; Ward, Michael D.; Yu, Lian; Alario-Franco, Miguel A.; Battle, Peter D.; Bein, Thomas; Cahill, Christopher L.; Halasyamani, P. Shiv; Maignan, Antoine; Seshadri, Ram.  Report from the third workshop on future directions of solid-state chemistry: The status of solid-state chemistry and its impact in the physical sciences. Progress in Solid State Chemistry 2007, 36(1-2), 1-133.
  28. Swallen, S.; Kearns, K.; Mapes, M.; McMahon, R.; Kim, S.; Ediger, M.; Yu, L.; Wu, T.; Satija, S.  Extraordinarily Stable Glassy Materials Prepared by Vapor Deposition.  Science 2007, 315, 353 – 356.
  29. Huang, J.; Chen, S.; Guzei, I. A.; Yu, L. Discovery of a Solid Solution of Enantiomers in a Racemate-Forming System by Seeding.  J. Am. Chem. Soc. 2006, 128, 11985-11992.
  30. Wu, T.; Yu, L. Origin of Enhanced Crystal Growth Kinetics near Tg Probed with Indomethacin Polymorphs.  J. Phys. Chem. B 2006, 110, 15694-15699.
  31. Wu, T.; Yu, L. Surface Crystallization of Indomethacin below Tg.  Pharm. Res. 2006, 23, 2350-2355.
  32. Tao, J.; Yu, L. Kinetics of Cross-Nucleation between Polymorphs.  J. Phys. Chem. B 2006, 110, 7098-7101.
  33. Huang, J.; Yu, L. Effect of Molecular Chirality on Racemate Stability: α-Amino Acids with Non-polar R Groups.  J. Am. Chem. Soc. 2006, 128, 1873-1878
  34. Chen, S.; Xi, H.; Yu, L. Cross Nucleation between ROY Polymorphs. J. Am. Chem. Soc. 2005, 127, 17439-17444.
  35. Martin, O. M.; Yu, L.; Mecozzi, S. Solution self-assembly and solid state properties of fluorinated amphiphilic calix[4]arenas.  Chem. Commun. 2005, 39, 4964 - 4966 
  36. Yu, L.; Huang, J.; Jones, K. J. Measuring Free-Energy Difference between Crystal Polymorphs through Eutectic Melting.  J. Phys. Chem. B 2005, 109, 19915-19922.
  37. Chen, S.; Guzei, I. A.; Yu, L.  New Polymorphs of ROY and New Record for Coexisting Polymorphs of Solved Structures.  J. Am. Chem. Soc. 2005, 127, 9881-9885.
  38. Milton, N.; Pyne, A.; Mishra, D.; Yu, L. The Exploration and Use of Thermal Analytical Technologies During Formulation and Process Development of Freeze-Dried Products.  Amer. Pharm. Rev., 2003, 6, 46-51.
  39. Yu, L. Nucleation of One Polymorph by Another. J. Am. Chem. Soc. 2003, 125, 6380-6381.  Featured in Chem. & Eng. News, 2003, 81(May 19), 36 and Science News 2004, 166, 113-128.
  40. Yu, L. Growth Rings of D-Sorbitol Spherulites: Connection to Concomitant Polymorphs and Growth Kinetics. Cryst. Growth & Design 2003, 3, 967-971.
  41. Telang, C.; Suryanaryana, R.; Yu, L. Crystallization of D-mannitol in binary mixtures with NaCl: phase diagram and polymorphism.  Pharm. Res. 2003, 20, 1939-1945.
  42. Telang, C.; Yu, L.; Suryanaryana, R. Effective Inhibition of Mannitol Crystallization in Frozen Solutions by Sodium Chloride.  Pharm. Res. 2003, 20, 660-667.
  43. Yu, L.; Ng, K.  Glycine Crystallization during Spray Drying: The Effect of pH on Polymorphic and Salt Forms.  J. Pharm. Sci. 2002, 91, 2367-2375.
  44. Yu, L.  Red, Orange and Yellow Polymorphs of a Conformationally Flexible Molecule: Single-Crystal Spectroscopy, Optical Crystallography and Computational Chemistry. J. Phys. Chem. A 2002, 106, 544-550.
  45. Mitchell, C. A.; Yu, L.; Ward, M. D. Selective Nucleation and Discovery of Organic Polymorphs through Epitaxy with Single Crystal Substrates.  J. Am. Chem. Soc. 2001, 123, 10830-10839.
  46. Yu, L. Amorphous Pharmaceuticals - Preparation, Characterization and Stabilization. Adv. Drug Delivery Rev. 2001 48, 27-42.
  47. Yu, L.; Stephenson, G. A.; Mitchell, C. A.; Bunnell, C. A.; Snorek, S. V.; Bowyer, J. J.; Borchardt, T. B.; Stowell, J. G.; Byrn, S. R. Thermochemistry and Conformational Polymorphism of a Hexamorphic Crystal System.  J. Am. Chem. Soc. 2000, 122, 585-591.  Featured in Science News 2004, 166, 113-128 and Polymorphism in Molecular Crystals (a textbook by Joel Bernstein; Oxford Univ. Press, 2002).  
  48. Reutzel, S. M.; Russell, V.; Yu, L.  Molecular Basis for the Stability Relationships between Homochiral and Racemic Crystals of Tazofelone: A Spectroscopic, Crystallographic, and Thermodynamic Investigation, J. Chem. Soc. Perkin Trans 2 2000, 913-924.
  49. Yu, L.; Reutzel-Edens, S. M.; Mitchell, C. M. Crystallization and Polymorphism of Conformationally Flexible Molecules, Org. Process R&D 2000, 4, 396-402.
  50. Yu, L.; Milton, N.; Groleau, E.; Mishra, D.; Vansickle, R. Existence of a Mannitol Hydrate During Freeze-Drying and Practical Implications.  J. Pharm. Sci. 1999, 88, 196-198.
  51. Yu, L.; Reutzel, S. M.; Stephenson, G. A.  Physical Characterization of Polymorphic Drugs: an Integrated Characterization Strategy.  Pharm. Sci. Tech. Today 1998, 1, 118-127.
  52. Yu, L.; Mishra, D.; Rigsbee, D.  Determination of the Glass Properties of Mannitol Using Sorbitol as an Impurity.  J. Pharm. Sci. 1998, 87, 774-777.
  53. Yu, L. Relative Stability of Polymorphs: Constructing Quantitative Stability-Temperature Diagram from Melting, Eutectic Melting and Other Thermodynamic Data.  Pharm. Res. 1997, 14, 185S.
  54. Yu, L.; Mishra, D.; Rigsbee, D.; Vansickle, R.; Groleau, E.; Milton, N.  Solid-State Studies of Mannitol and Mannitol-Sorbitol Mixtures.  Pharm. Res. 1997, 14, 445S.
  55. Stephenson, G. A.; Borchardt, T. B.; Byrn, S. R.; Bowyer, J. J.; Snorek, S. V.; Bunnell, C. A.; Yu, L. Conformational and Color Polymorphism of LY290437.  J. Pharm. Sci. 1995, 84,1385.
  56. Yu, L.  Inferring Thermodynamic Stability Relationship of Polymorphs from Melting Data.  J. Pharm. Sci. 1995, 84, 966.
  57. Schwier, J.; Cooke, G.; Hartauer, K.; Yu, L.  Rayon: A Source of Furfural-A Reactive Aldehyde Capable of Insolublizing Gelatin Capsules.  Pharm. Tech. 1993, May, 78.
  58. Yu, L.; Cullin, D.; Williamson, J.; Miller, T.  High Resolution Laser Spectroscopy of Asymmetrically Deuterated Cyclopentadienyl Radicals: A Study of Vibronic Degeneracy Resolution and Jahn-Teller Distortion.  J. Chem. Phys. 1993, 98, 2682.
  59. Yu, L.; Williamson, J.; Foster, S.; Miller, T.  High Resolution Laser Spectroscopy of Free Radical- Inert Gas Complexes.  J. Chem. Phys. 1992, 97, 5273.
  60. Cullin, D.; Yu, L.; Williamson, J.; Miller, T.  High-Resolution Spectroscopy of Jet-Cooled Substituted Cyclopentadienyl Radicals.  J. Phys. Chem 1992, 96, 89.
  61. Yu, L.; Cullin, D.; Williamson, J.; Miller, T.  Rotationally Resolved Laser Spectroscopy of Methylcyclopentadienyl Radical and Deuterated Analog.  J. Chem. Phys. 1991, 95, 804.
  62. Chang, B.; Yu, L.; Cullin, D.; Rehfess, B.; Williamson, J.; Miller, T.; Fawzy, W.; Zheng, S.; Sei, P.; Heaven, M.  Rotational, Fine and Hyperfine Structure in the High Resolution Electronic Spectrum of ArOH and ArOD.  J. Chem. Phys 1991, 95, 7086.
  63. Yu, L.; Foster, S.; Williamson, J.; Miller, T.  High Resolution Electronic Spectroscopy of Jet-Cooled Hexa- and 1,3,5-trifluorobenzene Cations.  J. Chem. Phys. 1990, 92, 5794.
  64. Liu, X.; Yu, L.; Miller, T.  Jahn-Teller Induced Corrections to Rotational and Fine-Structure Parameters in Doubly Degenerate Electronic States.  J. Mol. Spectros. 1990, 140, 112.
  65. Cullin, D.; Yu, L.; Williamson, J.; Platz, M.; Miller, T.  Reinvestigation of the Electronic Spectrum of Phenyl Nitrene Radical.  J. Phys. Chem. 1990, 94, 3387.
  66. Liu, X.; Foster, S.; Williamson, J.; Yu, L.; Miller, T.  Spin-Rotation Interaction in Methoxy Radical.  Mol. Phys. 1990, 69, 357.
  67.  Yu, L.; Williamson, J.; Miller, T.  Rotationally Resolved Electronic Spectrum of Jet-Cooled Deuterated Cyclopentadienyl Radical.  Chem. Phys. Lett. 1989, 162, 431.
  68. Yu, L.; Foster, S.; Williamson, J.; Heaven, M.; Miller, T.  Rotationally Resolved Electronic Spectrum of Jet-Cooled Cyclopentadienyl Radical.  J Phys. Chem. 1988, 92, 4263.
  69. Liu, X.; Damo, C. P.; Lin, T. Y. D.; Foster, S. C.; Misra, P.; Yu, L.; Miller, T. A.   Free jet-cooled laser-induced fluorescence spectrum of methoxy radical. 2.  J. Phys. Chem. 1989, 93, 2266-75.
  70. Liu, L.; Damo, C.; Lin, D.; Foster, S.; Misra, P.; Yu, L.; Miller, T.  Free-Jet Cooled Laser-Induced Fluorescence Spectrum of Methoxy Radical. J. Phys. Chem. 1986, 93, 6766.

Book Chapters and Monographs

71.  Yu, L.  High-resolution laser spectroscopy of cyclopentadienyl radical
      and its derivatives in a supersonic free jet expansion.  (1991). CAN
      116:94462  AN 1992:94462.  Ph.D. Thesis.
72.  Yu, L.; Reutzel-Edens, S. M.  Crystallization Basic Principles. 
      Encyclopedia of Food Sciences and Nutrition.  Academic Press:
      London (2002).

Patents

  1. Yu, Lian; De Villiers, Melgardt M.; Wu, Tian.  Inhibiting surface enhanced crystallization of amorphous pharmaceuticals with ultrathin coatings.  U.S. Pat. Appl. Publ. (2008), 17pp.  CODEN: USXXCO  US  2008233157  A1  20080925  CAN 149:386401  AN 2008:1155830.
  2. Ediger, Mark D.; Swallen, Stephen; Kearns, Ken; Yu, Lian; Wu, Tian.  Unusually stable glasses and methods for forming same.  U.S. Pat. Appl. Publ.  (2008), 24pp.  CODEN: USXXCO  US  2008213365  A1  20080904  CAN 149:316008  AN 2008:1070389.
  3. Zhang, Geoff G. Z.; Yu, Lian; Tao, Jing; Sun, Ye; Maegerlein, Markus.  Method for evaluating the solubility of a crystalline substance in a polymer.    PCT Int. Appl.  (2009), 29 pp.  CODEN: PIXXD2  WO  2009135799  A2  20091112  CAN 151:536889  AN 2009:1394498
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